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Laboratory of Tumor Biology
   
László Kopper, MD, PhD, DSc
    Professor

In the past several years the lab activity was focused on those molecular targets which may play essential role both in the development, growth and progression as well as in the clinical management of cancer. One of the important regulatory factors is transforming growth factor beta (TGFb) with a capacity to block the proliferation of lymphoid cells. However, many lymphoid malignancies lost the responsiveness to TGFb. It has been shown that besides the traditional signaling (Smad) pathway an alternate route involving MAPK has equal importance. The missed capability of cancer cells to die is the consequence of the overproduction of survival factors. The EGFR-pathway can be activated at several levels. Our aim is to clarify the role of mTOR especially in combinations with other factors (mainly rapalogs). The survival can be supported or modified by the expression of those molecules which influence stem cell activity, e.g. the Notch-pathway. Different in vitro and in vivo techniques are used including gene transfer, PCR technology, sequencing, human tumor xenografts etc. Tissue microarray is a useful tool to search relavant biomarkers for cancer therapy as well as to understand the driving force in progression. One study was designed to identify differently expressed gene products in lung cancer with and without brain metastases. A set of 5 proteins were described. Similar technique is used in DBCL and Hodgkin lymphoma and the preliminary results suggest the unique expression of mTOR targets. More studies are under way on different solid tumors (e.g. colorectal cc, bone tumors) in order to select molecules for explaining pathogenesis and also to refine diagnostic targets. 		   
   
        
   
   
KEYWORD(S): cancer, targeted therapy, molecular diagnostics, signaling pathways, apoptosis, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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