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Clinical Nephrology Research Group
   
Istvan Mucsi, MD, PhD
    Associate Professor

Our research interest covers diverse areas, such as: 1) Molecular mechanisms of the progression of renal fibrosis; 2) renal and post-transplant anemia; 3) disorders of the calcium and phosphate metabolism in CKD patients; 4) cardiovascular morbidity in CKD patients; 5) malnutrition-inflammation complex syndrome (MICS).

In collaborations with laboratories in Europe and Canada we have identified salient intracellular signaling mechanisms contributing to the fibrogenic effects of angiotensin II and transforming growth factor-beta. We have also studied the regulation of epithelial-mesenchymal transition in renal tubular epithelial cells.

We have studied the prevalence and clinical significance of vitamin D deficiency in dialysis patients and assessed the effect of native vitamin D supplementation in these patients. We have collected data on the significance of reduced bone density in dialysis patients.

Currently we study the association between calcium and phosphate metabolism, renal bone disease and reduced bone mass versus cardiovascular calcification, endothelial dysfunction and morbidity and mortality.

Finally, we have assessed the correlates of anemia both in dialysis and kidney transplanted patients in cross sectional studies. In a large prospective cohort study we have demonstrated that anemia predicts mortality in kidney transplanted patients. Now we assess the association of the malnutrition-inflammation complex syndrome with bone disease, anemia and morbidity and mortality in kidney transplanted patients.

Dr. Mucsi is an internationally recognized nephrologist with a strong interest in interdisciplinary research, intracellular signaling and clinical epidemiology. He has published 64 papers, 15 book chapters. Internationally he has active collaborations both in Europe (The United Kingdom, Finland, Germany) and in North America (Canada, Ann Arbor Collaborative for Health, US). His cumulative impact factor is 122, Hirsch index 14 with 603 independent citations. 		   
   
        
   
   
KEYWORD(S): molecular mechanisms of renal fibrosis, renal anemia, chronic inflammation, cardiovascular disease, disorders of calcium and phosphate metabolism, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Clinical Nephrology Research Group  Laboratory of Comparative Neurocytology and Neuroethology  Corneal and Refractive Surgical Unit  Glaucoma Clinical and Research Group  Molecular and Cellular Neuroendocrine Research Laboratory  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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