View   
     List   
     FAQ   
  Home   /  Internal medicine and pediatrics  /  Diabetes and Metabolism Study Group  
  Config  
 | 
  Log in (Admin)  
    
     
 
   
Diabetes and Metabolism Study Group
   
Aniko Somogyi, MD, PhD, DSc
    Associate Professor

Investigation of pathomechanism of diabetes and its late complications

Diabetes and Genetics:
Although the most common form of diabetes has a complex genetic background involving numerous genetic and environmental risk factors, only a few components are well documented. Our study group is designated to search for novel risk-factors of T2DM, and particularly concentrates on the interaction of environmental and genetic risk-factors. Our final goal is a better understanding of the complex environmental and genetic background of T2DM.

Diabetes and Depression:
Clinical evidence suggests that the prevalence of depression is twice as high in diabetic patients compared to the general population. The presence of depression has a negative effect on the compliance of diabetic patients, increasing the frequency of diabetes complications. Our study group sets out to investigate the possible causes, effects, and   of this co-morbidity (i.e gene environment interactions).
Methods: DNA sampling. Self reported depression and anxiety questioners.

Diabetes and the Incretin system:
Dysfunction of entero-insular axis and the failure of islet beta-cell adaptation might contribute to the development of T2DM in addition to and independently from other well known factors, such as insulin resistance. In our study we are investigating if there is any alteration in the entero-insular axis (serum DPP-4 activity and Incretin hormone levels -fasting and prandial) in patients with T2DM compared to healthy controls.
Methods:Elisa

Diabetes and it’s complications:
The pathogenesis of the late complications of diabetes mellitus is still unclear from many aspects. In diabetes as a result of hyperglycaemia increased oxidative stress causes endothelial dysfunction. Endothelial dysfunction is one of the first signs of late diabetic complications and it is a result of a complex malfunction of many endothelium derived relaxation and contracting factors. Our study group conducts in vivo and in vitro human and animal studies. Our recent investigations discuss changes of oxidative stress, antioxidants, (vitamin A and E), vasoactive peptides (such as Endothelin 1 and Adrenomedullin) and the NO/cGMP pathway during fasting and postprandial states.
Methods: Radioimmunoassay, Elisa, Electron Spin Resonance Spectroscopy, HPLC. 		   
   
        
   
   
KEYWORD(S): diabetes, arteriosclerosis, oxidative stress, depression, genetic, 
   
  1 - 2 (2)     
 
  1 - 2 (2)     
 
  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Diabetes and Metabolism Study Group  Laboratory of Cerebrovascular Research  Pediatric Nephrology Research Group  Antibiotic Resistance Research Unit  Ocular Surface and Cornea Laboratory  Clinical Nephrology Research Group  Laboratory of Comparative Neurocytology and Neuroethology  Corneal and Refractive Surgical Unit  Glaucoma Clinical and Research Group  Molecular and Cellular Neuroendocrine Research Laboratory  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
    :: © 2009 - Semmelweis University :: Production - DataWeb Systems ::