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Hepatology Unit
   
Ferenc Szalay, MD, PhD, DSc
    Professor

The main field of our scientific activity is clinical research on liver diseases. We study the hepatic and extrahepatic complications of chronic liver diseases as metabolic bone disease and autonomic neuropathy. We investigate epidemiological, clinical and genetic aspects of Wilson disease using advanced molecular biological methods. Different aspects of chronic intrahepatic cholestatic liver diseases as primary biliary cirrhosis are also investigated. Serum osteoprotegerin, leptin, soluble leptin receptor, alfa2HS glycoprotein, dipeptidyl-peptidase (DPP IV), sensory and autonomic neuropathy, the endothelial function is investigated in primary biliary cirrhosis, chronic C hepatitis and other liver diseases. The biliary and hepatic complications of inflammatory bowel diseases were also studied.
We perform investigations in experimentally induced liver cirrhosis and hepatocellular carcinoma model in rat as well. Bone abnormalities and nociceptin (endogenous opioid like receptor agonist) alterations were detected.
Our work is performed in frame of national and international cooperation. We participate in the work of EuroWilson study group presenting epidemiological and clinical data to the European database. We described new mutations of ATP7B gene in Wilson diseases patients from Hungary.
We contribute to the liver transplantation program in Hungary. More that 300 liver transplantation have been performed. The pre and post transplantation care, the research on osteopathy, autonomic function is a subject of our ongoing work.
We participate in a number of international multicenter clinic pharmacological trials on the treatment of chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis and complications of liver cirrhosis as portosystemic encephalopathy and ascites.
Our results may contribute to the better understanding of the pathomechanism of liver diseases and their complications, and also to the earlier diagnosis and appropriate treatment. 		   
   
        
   
   
KEYWORD(S): hepatic osteopathy, Wilson disease, autonomic neuropathy, viral hepatitis, primary biliary cirrhosis, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Hepatology Unit  Reproductive Neuroendocrinology Laboratory  Genetics Unit  Biochemistry, cell biology, biophysics  Clinical Neurophysiology Laboratory  Neuroendocrine Research Laboratory  Salivary Research Laboratory  Neurobiochemical Research Group  Neurochemical Research Unit  Pharmaceutical sciences, pharmacology  Biochemical Research Group  Immunohistological Laboratory  Experimental and clinical oncology  Internal medicine and pediatrics  Molecular biology, microbiology  Sleep Medicine Unit  Medicine of sensory organs  Physiology, pathophysiology  Heart Center  www  Behavioural sciences   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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