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Pediatric Nephrology Research Group
   
György Reusz, MD, DSc
    Professor

Our research is based on two pillars: first, the description of the genetic background of kidney injury in children with urinary tract infections (UTI), the most common cause of kidney damage in children and a specific model involving genes of innate immunity following renal transplantation (Tx).

Second, non-invasive monitoring used to assess cardiovascular damage of CRF.

1. Gene polymorphisms. We studied the role of the heat shock proteins (HSP) and the toll like receptors (TLR) on recurrent UTI and on long-term graft survival following Tx. The presence of the alleles HSPA1B 1267G and TLR4 896G increase the risk of recurrent UTI independently of other factors, which requires the reconsideration of the actual therapeutic strategies (chemoprophylaxis).

TLR4 299G was coupled with long term graft survival indicating a decreased proinflammatory response and protection against acute rejection. The presence of HSP72 1267G is cytoprotective and increases graft survival.

2. CV damage is the leading cause of morbidity and mortality among patients with chronic renal failure. Studies in adults suggest that transplantation may reduce the overall cardiovascular risk caused by CRF by slowing down and/or even reversing the involved pathological processes. Autonomic nervous dysfunction (AND) and arterial stiffness (AS) are independent CV risk factors CRF.

Heart rate variability (HRV) is used to characterize AND, whereas pulse wave velocity (PWV) serves as a measure of arterial stiffness. According to our results AND is already present in children with CRF, it is due to sympathetic overactivity and is reversible following Tx. We established pediatric normal values for PWV. PWV is increased in Tx compared to healthy controls and decreased compared to CRF. Disturbed Ca-P metabolism and the calcitriol treatment before transplantation may have a major role in determining arterial stiffness after transplantation. Renal transplantation may have a beneficial effect on PWV. 		   
   
        
   
   
KEYWORD(S): uremia, transplantation, cardiovascular risk, pulse wave velocity, calcium metabolism, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Pediatric Nephrology Research Group  Antibiotic Resistance Research Unit  Ocular Surface and Cornea Laboratory  Clinical Nephrology Research Group  Laboratory of Comparative Neurocytology and Neuroethology  Corneal and Refractive Surgical Unit  Glaucoma Clinical and Research Group  Molecular and Cellular Neuroendocrine Research Laboratory  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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