View   
     List   
     FAQ   
  Home   /  Medicine of sensory organs  /  Laboratory of Corneal Wound Healing  
  Config  
 | 
  Log in (Admin)  
    
     
 
   
Laboratory of Corneal Wound Healing
   
Ildikó Süveges, MD, PhD, DSc
    Professor

Ocular surface diseases concern both the conjunctiva and the cornea. The latter is the most important refractive medium of the eye. It is transparent; and its degree of transparency does not alter during the lifetime of a healthy individual. It normally contains no blood vessels. The wound-healing process of the cornea is of a very special kind since, provided that the wound does not involve the perilimbal area, cells other than keratocytes play no part in the process.
 For the normal integrity of the cornea to be preserved, the presence of a healthy epithelium is indispensable. If the epithelium is damaged or missing, then in the absence of rapid reepithelisation corneal ulcer, inflammation, and consequent loss of transparency will usually result. Epithelial cells regenerate from the stem cells of the limbus, and if these latter cells are lacking or damaged, this will in turn lead to a deficit of corneal epithelium, with its adverse consequences. Fortunately however the limbal stem cells can be successfully cultured, under certain special conditions. Autologous or homologous transplants of these cells can allow the management of ocular surface diseases caused by a lack of limbal stem cells.

In a major part of our present study we are culturing limbal stem cells, working with the assistance of colleagues at the Institute of Experimental Medicine of the Hungarian Academy of Sciences. The resulting cultured cells can easily be removed from the fibrin culturing layer and implanted onto the surface of an injured eye. However, further studies are required to establish how well the cell-transplant survives in the ocular environment.
Limbal stem cells can also be replaced using homologous transplants, employing donor corneas. Exploration of the most appropriate techniques for this surgery comprises a further area of our research work. The reason for such transplants being able to heal without tissue rejection is not yet fully understood. In this case, corneo-scleral tissue is implanted; but despite the fact that scleral transplants are highly vascularised, rejection does not occur.

A further aim of our study is to attempt to elucidate the role of toll-like receptors in the vascularisation of the cornea. These receptors may play a part in corneal inflammation, but this mechanism has up to now not been studied for the cornea. 		   
   
        
   
   
KEYWORD(S): corneal dystrophies, stem cells, wound healing, keratoplasty, 
   
  1 - 2 (2)     
 
  1 - 2 (2)     
 
  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
    :: © 2009 - Semmelweis University :: Production - DataWeb Systems ::