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Ocular Surface and Cornea Laboratory
   
János Németh, MD, PhD, DSc
    Professor and Chair

1. Ocular surface. Besides investigation of the tear film dynamics, including definition of tear film build-up time, instrumental development of a new corneal suface examination method is performed. Mathematical description of the corneal surface by polynomials in cooperation with the MTA SZTAKI and ELTE has been published. Changes in the frequency of blinking in different circumstances is investigated.

2. Refractive surgery. Corneal wound healing and the role of secondary UV-B irradiation after different techniques of refractive surgery (PRK, LASIK, LASEK) were analyzed. Higher order aberrations are measured in healthy volunteers and in patients after refractive surgery.

3. Corneal histopathology. The pathways of apoptosis of corneas with Fuchs' dystrophy, pseudophakic bullous keratopathy and keratoconus are studied. We determine by means of immunohistochemical analysis the expression of p21, p27, p63, survivin, CD95, cathepsin, bax, bcl-2 and Ki67 in the above corneal pathologies. We determine, wheather apoptosis is a pathogenic factor or the consequence of the disfuncion of the corneal cells in the above conditions. Classification of corneal amniotic membrane integration patterns was published on histopathological, immunohistochemical and electron microscopic bases.

4. Genetics of corneal wound healing. A PCR-based mutation analysis of cornea-specific small keratan sulfate proteoglycans, lumican and keratocan genes, was carried out to investigate whether germline genetic alterations have an effect on development of severe corneal haze occurring after photorefractive keratectomy (PRK)  in humans. In the same group of patients we examined  the role of three functional polymorphisms of the glucocorticoid receptor gene in ocular hypertension using PCR and RFLP methods. We found  a significant association between N363S heterozygosity and steroid-induced ocular hypertension occuring after administration of topical prednisolon acetate 0.5% eyedrops after PRK. 		   
   
        
   
   
KEYWORD(S): cornea, tear film, ocular surface, topography, amniotic membrane, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Ocular Surface and Cornea Laboratory  Clinical Nephrology Research Group  Laboratory of Comparative Neurocytology and Neuroethology  Corneal and Refractive Surgical Unit  Glaucoma Clinical and Research Group  Molecular and Cellular Neuroendocrine Research Laboratory  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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