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Biochemical Research Group
   
Anna Blázovics, PhD, DSc
    Redox homeostasis can be considered as the cumulative action of free radicals and antioxidant defense, providing a suitable condition for life. Antioxidant consumption is sine qua non for a healthy way of life, but the concentration range is large and dependent on an individual genetic background. Moderate nutritional customs with natural scavengers or antioxidants can help to restore the normal function of tissues and organs, but the immoderate consumption of vitamins and other bioactive agents is contraindicated. The balance between oxidative stress and antioxidant defense is turned over in diseases. Moderate oxidative stress is important in signal transduction pathways and essential for proliferation and apoptosis. Antioxidant overflow as well as oxidative stress means a serious problem. Diet related bioactive compounds are intensively examined in vitro, although their in vivo and in vitro effects are different and the modes of actions in in vivo are not yet known in detail. Several active agents are important in cancer prevention as well. Metals are also important both in free radical formation and in antioxidant defense in signal transduction.
Our research group aims to study the effects of bioactive small molecules and metal element rich drugs, fruit and vegetable concentrates or special foods on the redox parameters in gastrointestinal diseases; the roles of the metal elements and methylating process in redox homeostasis.
The levels of our scientific program are:
In vitro studies: We have developed several spectrophotometric, luminometric and fluorometric measurements to determine the svavenging property and antioxidant capacity of natural products.
In vivo experimental studies: Animal models (fatty liver, partial hepatectomy, ischaemia-reperfusion, extrahepatic cholestasis models) have been used to study the biological effectiveness of special foods and drugs. Methods for routine laboratory parameters, immune parameters, redox parameters and elements of liver, plasma and erythrocyte have been applied to study the bioavailability of bioactive agents (functional foods).
In vivo human studies: Special food supplementation of patients with liver and other gastrointestinal diseases as well as cancer patients in interval of chemotherapy and/or x-ray therapy has been studied. 		   
   
        
   
   
KEYWORD(S): redox homeostasis, free radical reactions, functional foods, bioavailability, gastrointestinal diseases, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Biochemical Research Group  Immunohistological Laboratory  Experimental and clinical oncology  Internal medicine and pediatrics  Molecular biology, microbiology  Sleep Medicine Unit  Medicine of sensory organs  Physiology, pathophysiology  Heart Center  www  Behavioural sciences   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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