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Molecular and Cellular Neuroendocrine Research Laboratory
   
György M. Nagy, MD, PhD, DSc
    Professor

Nowadays, it is clear that the biological actions of prolactin are not limited solely to reproduction, rather it controls variety of behaviors and more importantly, it plays an indispensable role in control of the homeostasis. Bidirectional communications likely exist between major players of the hypothalamic centers controlling internal milieu, like osmoregulation, metabolism, reproduction and/or the most important hypophysiotrophic (like neuroendocrine dopaminergic) neurons of the endocrine homeostasis. Based on this consideration, it is not surprising that neuropeptides can directly (at the pituitary level) and/or indirectly (through the hypothalamus) influence prolactin release from the pituitary gland. At the same time, prolactin can play a role in the mediation of the influences of the above mentioned systems on target organs, like fluid and electrolite transport trough mammary epithelial cells and/or through its action as an adipokine on fat cells. Moreover, prolactin can feed back hypothalamic neuroendocrine neurons that have a relationship with other homeostatic regulatory centers. According to our working hypothesis all of these communications are required for the adequate control of the internal milieu, therefore, several aspects of them are targets of our research projects. It is also obvious, that the most precise knowledge about signal transduction mechanisms of pituitary D2-type dopamine receptors is required to understand not only the physiological significance of the desensitization/sensitization processes but the dominant and tonic inhibition of mammotropes exercised by the hypothalamic dopaminerg neurons. Learning more about dopamine signaling mechanisms regulating cell survival (including the inhibition of the apoptotic cascade) in the anterior lobe of the pituitary gland, as an integral part of the tonic inhibition of prolactin secretion, hopefully give us a new and effective way for treatment of prolactnomas as well as other pituitary tumors. 		   
   
        
   
   
KEYWORD(S): pituitary, hypothalamus, dopamine, neuropeptides, receptor signaling, 
   
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  Molecular and Cellular Neuroendocrine Research Laboratory  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
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Biochemistry, cell biology, biophysics

  

Dental sciences

  

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Medicine of sensory organs

  

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