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Neurobiochemical Research Group
   
Vera Ádám-Vizi, MD, PhD
    Professor, Member of the Hungarian Academy of Sciences

Mitochondrial dysfunction and reactive oxygen species (ROS) are involved in the pathogenesis of acute and chronic brain diseases. Mitochondria are susceptible to ROS-mediated functional injury, but also responsible for the generation of ROS. One of the aims of our team is to reveal mitochondrial mechanisms and molecules responsible for the ROS production. Special emphasis is put on the regulation of ROS production by in situ mitochondria present in their normal intracellular environment.

Permeability transition could also be part of the pathological scenario leading to neuronal cell death. Understanding the molecular details of mitochondrial permeability transition pore (mPTP) is important to elaborate effective cytoprotective strategies. Using tissue culture of genetically modified mice (lacking components of PTP), changes in mitochondrial functions and morphology are studied with microfluorimetric methods developed in our laboratory.

We have recently developed an online kinetic assay for the adenine nucleotide translocase (ANT) activity. Based on this assay, a computer model was developed to predict ANT activity as a function of mitochondrial membrane potential, as well as 22 other mitochondrial parameters to investigate the conditions mimicking tissue ischemia in which mitochondria become ATP consumers. Using the ANT assay and the computer model, we are establishing a diagnostic test for mitochondrial dysfunction-related myopathies. 		   
   
        
   
   
KEYWORD(S): brain, oxidative stress, excitotoxicity, mitochondria, neurodegeneration, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Neurobiochemical Research Group  Neurochemical Research Unit  Pharmaceutical sciences, pharmacology  Biochemical Research Group  Immunohistological Laboratory  Experimental and clinical oncology  Internal medicine and pediatrics  Molecular biology, microbiology  Sleep Medicine Unit  Medicine of sensory organs  Physiology, pathophysiology  Heart Center  www  Behavioural sciences   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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