View   
     List   
     FAQ   
  Home   /  Neurosciences  /  Neurochemical Research Unit  
  Config  
 | 
  Log in (Admin)  
    
     
 
   
Neurochemical Research Unit
   
Kálmán Magyar, MD, PhD, DSc
    Professor Emeritus, Member of the Hungarian Academy of Sciences

The role of aminoxidases in neuro- and vasoprotection

Two families of aminoxidases; namely monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) are investigated in our group, in respect of neuro- and vasoprotection.

(-)-Deprenyl (selegiline) is a selective inhibitor of MAO-B, which is widely used in the treatment of neurodegenerative diseases. The principal objective of our present studies is to improve the therapeutic spectrum of the inhibitor.

Selegiline has an intensive “first pass” metabolism after oral application. Less than 25% of the parent compound reaches the systemic circulation. Our aim is to develop parenteral drug formulas (transdermal, liposomal preparations, etc.), which increase the bioavailability of the compound. In these cases the significant inhibition of MAO-A, without influencing enzyme activity in the liver and the gastrointestinal tract, leads to a new spectrum of activity (antidepressive).

The metabolites of selegiline with propargylamine group possess neuroprotective activity, which was demonstrated at much lower concentrations, than it is needed for MAO inhibition. Deprenyl-N-oxide (DNO) displays remarkable neuroprotective properties. DNO, in contrast to selegiline, even at high concentrations does not possess pro-apoptotic properties. Changing the pharmacokinetic profile of selegiline its therapeutic indication can be widened (effective in depression, AD/HD, withdrawal syndrome, etc.). It is rational, that selegiline and its congeners might be effective to treat co–morbidities.

SSAO exists in soluble and solid form. Its functional role still is still not discovered. Our aim is to develop new inhibitors, better than semicarbazide to elucidate the consequences of SSAO inhibition in therapy. Inhibitors are synthesized in collaboration and screened in our laboratory.

The topic of neuro- and vasoprotection belongs to the leading line of pharmacological research, possessing social impact and practical benefit.    		   
   
        
   
   
KEYWORD(S): deprenyl, neuroprotection, pharmacokinetics, monoaminoxidase, semicarbazide-sensitive aminoxidase, 
   
  1 - 2 (2)     
 
  1 - 2 (2)     
 
  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Neurochemical Research Unit  Pharmaceutical sciences, pharmacology  Biochemical Research Group  Immunohistological Laboratory  Experimental and clinical oncology  Internal medicine and pediatrics  Molecular biology, microbiology  Sleep Medicine Unit  Medicine of sensory organs  Physiology, pathophysiology  Heart Center  www  Behavioural sciences   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
    :: © 2009 - Semmelweis University :: Production - DataWeb Systems ::