Research Database - Semmelweis University

View

List

FAQ

Home

Neurosciences

Neuroendocrine Research Laboratory

Config

Neuroendocrine Research Laboratory

Béla Halász, MD, PhD, DSc

Research Professor, Member of the Hungarian Academy of Sciences

The research unit, supported by the Hungarian Academy of Sciences and the Department of Human Morphology and Developmental Biology of the Semmelweis University, studies since decades the central nervous system - anterior pituitary - target endocrine gland system. Presently we are primarily interested in the structural and functional aspects of the glutamatergic innervation of prominent hypothalamic cell groups. We use vesicular glutamate transporters as markers of glutamatergic elements and inject glutamate receptor antagonists into various hypothalamic structures to examine the functional significance of the glutamatergic innervation. As techniques autoradiography, single and double label immunocytochemistry at the light and electron microscopy level are applied, by means of minipumps drugs are injected into hypothalamic cell groups via implanted cannula, we determine hormones by radioimmunoassay. - In the last five years we have reported that in the hypothalamus glutamatergic fibers terminate on gonadotropin-releasing hormone- containing neurons, on growth hormone-releasing hormone-containing nerve cells and on somatostatin immunoreactive neurons. Further we have demonstrated that glutamate receptor antagonist injected into the hypothalamus blocks the suckling stimulus-induced release of prolactin, and inhibits the prolactin response to formalin stress. By means of radiolabeled aspartate autoradiography, we mapped the location of glutamatergic neurons projecting to hypothalamic cell groups. - Currently we study the glutamatergic innervation of the suprachiasmatic nucleus, key-structure of the control of circadian rhythms, and investigate the effect of sex steroids on the glutamatergic neurons in various structures of the brain.

KEYWORD(S): hypothalamus, glutamatergic, vesicular glutamate transporters, anterior pituitary, synaptic connections,

1 - 2 (2)

1 - 2 (2)

KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,

Neuroendocrine Research Laboratory Salivary Research Laboratory Neurobiochemical Research Group Neurochemical Research Unit Pharmaceutical sciences, pharmacology Biochemical Research Group Immunohistological Laboratory Experimental and clinical oncology Internal medicine and pediatrics Molecular biology, microbiology Sleep Medicine Unit Medicine of sensory organs Physiology, pathophysiology Heart Center www Behavioural sciences

Research Areas

Behavioural sciences

	Clinical Psychiatry Research Group
	Mental Health Research Group
	www

Biochemistry, cell biology, biophysics

	Chaperone and Network Group
	Drug Target Interactions Unit
	Endoplasmic Reticulum Research Group
	Functional Protein Dynamics Laboratory
	Hemostasis Group
	Laboratory of Cell Biology, Section of Vascular Neurology
	Laboratory of Ion Channel Research
	Laboratory of Molecular Endocrinology
	Pathobiochemistry Research Group
	Signal Transduction Laboratory

Dental sciences

	Molecular Oral Biology Research Group
	Salivary Research Laboratory

Experimental and clinical immunology and genetics

	Acute Phase Reaction Research Group
	Clinical Genomics Unit
	Experimental Renal Research Group
	Immunogenomics and Immunomics
	Immunology Laboratory of Pulmonary Diseases
	Inflammation Immunology Group
	Laboratory of IF and Genetics
	National Angioedema Center
	Research Group of Immunogenetic and Complement Investigations
	Research Group of Inflammation Biology and Immunogenomics

Experimental and clinical oncology

	Laboratory of Tumor Biology
	Molecular Therapy Laboratory
	Proteoglycan Research Group

Internal medicine and pediatrics

	Clinical Nephrology Research Group
	Clinical Research Laboratory
	Diabetes and Metabolism Study Group
	Division of of Haematology
	Endocrinological Research Group
	Hepatology Unit
	Lipid and Atherosclerosis Research Group
	Molecular Genetic Unit
	Neuropathy Research Group
	Pediatric Nephrology Research Group
	Pediatric Research Group
	Research Group of Metabolism and Clinical Genetics
	Unit of Molecular Mechanisms of Gastroenterological Disorders

Medicine of sensory organs

	Corneal and Refractive Surgical Unit
	Glaucoma Clinical and Research Group
	Laboratory of Corneal Wound Healing
	Ocular Surface and Cornea Laboratory

Miscellaneous

	Biochemical Research Group
	Heart Center
	Photocarcinogenesis, Photodermatology Unit
	Sleep Medicine Unit

Molecular biology, microbiology

	Antibiotic Resistance Research Unit
	Genetics Unit
	Laboratory of Molecular Genetics

Morphological sciences (anatomy, pathology, forensic medicine)

	Developmental Biology Laboratory
	Laboratory of Experimental Liver Pathology
	Liver Pathology Research Unit
	Oncohaematology Laboratory

Neurosciences

	Clinical Neurophysiology Laboratory
	Immunohistological Laboratory
	Laboratory of Cell and Molecular Biology
	Laboratory of Comparative Neurocytology and Neuroethology
	Molecular and Cellular Neuroendocrine Research Laboratory
	Neurobiochemical Research Group
	Neurochemical Research Unit
	Neuroendocrine Research Laboratory
	Neuromorphological and Neuroendocrine Research Laboratory
	Reproductive Neuroendocrinology Laboratory
	Research Group for Stroke and Dementia
	Sleep Research and Psychophysiology Group

Pharmaceutical sciences, pharmacology

	Application of Bioanalytical Methods in Pharmaceutical Research
	Biochemical Pharmacology Unit
	Gastroenterological Research Laboratory
	Medicinal Chemistry Research Group, Rational Drug Design Laboratory
	Opioid Research Group
	Research Group for Drug Profiling and Analysis
	Research Group of Phytochemistry and Pharmaceutical Biotechnology
	Research Laboratory for Organic and Medicinal Chemistry
	Stability Research Group

Physiology, pathophysiology

	Cardiovascular and Volume Homeostasis Research Group
	Cerebrovascular Signaling Research Group
	Clinical Cardiovascular Laboratory
	Immunology of Renal and Vascular Diseases Group
	Inflammation Research Unit
	Laboratory of Cerebrovascular Research
	Laboratory of Molecular Endocrinology
	Laboratory of Reactive Oxygen Species Research
	Laboratory of Tissue Engineering
	Laboratory of Vascular Physiology
	Molecular Biology Laboratory
	Nephrology Research and Training Center
	Phagocyte Research Group

Reproductive sciences

	Division of Assisted Reproduction
	Gene and Enviroment

Sport sciences

	Research Institute of Sport Science
	Research Laboratory of Biomechanics

Surgery (operative sciences)

Unit of Pelvic Floor Dysfunction