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Neuromorphological and Neuroendocrine Research Laboratory
   
Miklós Palkovits, MD, PhD, DSc
    Professor, Member of the Hungarian Academy of Science

The research studies are aimed to reveal the identity, the topography and the chemical characters of new pathways which constitute functional neuronal circuits in and between the hypothalamus and the central autonomic system. The research activity includes neuromorphological investigations of central regulatory mechanisms, like food intake, pain, stress and neurohumoral effects on the sympathetic outflow. Information obtained from this study may help to introduce a new attitude in neuroscience, the “system neuromorphology”. Major deliverables: 1) Localization of dorsolateral hypothalamic projections to medullary parasympathetic and spinal sympathetic preganglionic neurons. 2) Neuroanatomical and neurochemical studies on the neuronal connections between the ventromedial and other, food intake-related neurons in mice. 3) Topographical localization and neurochemical characterization of the ulcus-related cortico-amygdaloid-vagal neuronal pathways in rats. 4) Topographical localization, neurotransmitters and neuropeptides in the trigemino-hypothalamic pathway. 5) Topographical distribution of the stomach- and duodenum-innervating sympathetic and parasympathetic premotor neurons in the hypothalamus, limbic system and the lower brainstem. 6)  Selective brainstem and spinal cord projections from peptidergic neurons of the arcuate nucleus. 7) The Human Brain Tissue Bank (HBTB) has been established and kept in operation by the Neuromorphological Research Group. The HBTB is unique for two important reasons: a) Microdissection of over 100 different brain nulei is performed on frozen brains and the samples are kept on -70 oC. These samples have been improved to be excellent for neuroendocrine, molecular genetic, proteomic and various types of neurochemical microassay and microarray studies. b) Very short post mortem delay:  brains were removed from the skull and frozen within 2-6 hours after death. The collection of the HBTB consists over 32000 samples. 		   
   
        
   
   
KEYWORD(S): food intake, stress, pain, neuroanatomy, neurochemistry, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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