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Cerebrovascular Signaling Research Group
   
Zoltán Benyó, MD, PhD, DSc
    Associate Professor

Vascular diseases are the most prevalent life-threatening diseases in industrialized countries, and are rapidly increasing in importance in the developing world. In the recent Oxford Vascular Study cerebrovascular events were found to be the most frequent acute manifestation of vascular diseases (Rothwell et al., Lancet 366: 1773-83, 2005). Although cerebrovascular disorders have been studied extensively, several important questions could not be clarified with experimental approaches based only on classical pharmacological tools. The advent of new gene targeting techniques opened the door for better understanding of complex physiological functions of the cerebral vasculature and their disturbances in diseases. Using transgenic animal models we are currently studying the following questions:

How do nitric oxide synthase, cycloxygenase and heme oxygenase pathways interact in the regulation of the cerebral circulation under physiological conditions and during hypoxia and hypercapnia.?

Which receptor(s) and potential secondary vasoactive agents mediate the cerebrovascular effects of nicotinic acid? Are these mechanisms involved in the mediation of cerebral hyperemia and edema formation in pathological states such as acute liver failure and endotoxemia?

Which NADPH oxidases are responsible for the enhanced cerebrovascular reactive oxygen species production and the consequent vasoregulatory dysfunction in diabetes? Which G protein coupled receptor (GPCR) mediated signaling pathways are involved in the activation of cerebrovascular NADPH oxidases in diabetes?

Which intracellular signaling mechanisms mediate the contractile effect of thromboxane-receptor activation in the cerebrovascular smooth muscle? Which of these pathways are important in the development of cerebrovascular dysfunction and vasospasm after subarachnoid hemorrhage and traumatic brain injury (TBI)?

Which GPCRs and downstream signaling pathways mediate the increased release of endothelin-1 and disruption of the blood brain barrier after TBI? 		   
   
        
   
   
KEYWORD(S): cerebral circulation, vascular smooth muscle, endothelium, signal transduction, cerebral ischemia, 
   
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  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
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