View   
     List   
     FAQ   
  Home   /  Physiology, pathophysiology  /  Laboratory of Cerebrovascular Research  
  Config  
 | 
  Log in (Admin)  
    
     
 
   
Laboratory of Cerebrovascular Research
   
Péter Sándor, MD, PhD, DSc
    Professor

Cerebrovascular diseases belong to the leading causes of death in Hungary. Rational therapy of these pathophysiologic disturbances can not be carried out without a detailed map about the main elements and mechanisms participating in the physiological regulation of the cerebral blood supply. Investigation of the role of perivascular nerves, NO, PARP enzyme and non-perikaryal elements of the brain (axons, olygodendrocytes, endothelial cells, blood-brain barrier) in the regulation of cerebral blood flow (CBF) is incomplete, especially in connection with diseases leading to brain ischemia: blood loss, circulatory shock, diabetes and stroke.  Investigation of this regulatory role of the non-perikaryal elements was in the focus of our studies. The main findings, obtained in anesthetized animals, in cerebrocortical microvessels,  or in endothelial cell cultures are as follows: (1) Vasodilatory action of the CO2 in the cerebrovascular bed is mediated by nitric oxide /NO/ (2) In brain ischemia, caused by severe arterial hypotension, the classic vasodilatory effect of CO2 is reversed: increased PaCO2 results in decreased CBF. (3) In the decompensated phase of the hemorrhagic shock the blood-brain barrier function is lost, mainly because the expression of occludin and cadherin is dramatically reduced. (4) Painful somatic afferent stimulation results in a significant increase of the regional cerebral blood flow (thalamus, somatosensory cortex) while total cerebral blood volume remains unchanged at the same time (5) Endothelium-dependent cerebral vasodilation is significantly reduced in  insulin-resistant  animals: this is a consequence of disturbed cyclooxigenase mediated processes,  without simultaneous change in the NO-mediated vasodilatory processes. (6) The PARP enzyme plays an important role in the development of ischemic brain damage: selective blockade of  PARP results in a significant decrease of the infarct area of the brain, both in the gray and in the white matter. 		   
   
        
   
   
KEYWORD(S): cerebral blood flow, cerebral blood volume, CO2-sensitivity, autoregulation, blood-brain barrier, 
   
  1 - 2 (2)     
 
  1 - 2 (2)     
 
  KEYWORD UNIVERSE: CO2-sensitivity, GTPase activating proteins - GAPs, NADPH oxidase - NOX2, NADPH oxidase, Neutrophilic granulocytes, TASK, TRESK, aging, apoptosis, asthma, autonomic neuropathy, autoregulation, avian, bioinformatics, blood-brain barrier, c, calcineurin, calcium, cancer, cell biology, cell fusion, cerebral blood flow, cerebral blood volume, complement, dendritic cells, diabetes, dopamine, duplikation, early restenosis, embryo, embryomanipulation, endoplasmic reticulum, endothelium, enviroment, epidemiology, exercise, gene expression, gene, genetics, hydrogen peroxide, hypothalamus, immunology, in vitro fertilization, inflammation, ischemia-reperfusion, liver, lupus nephritis, lymphoid tissue, medicinal chemistry, metabolic bone disease, mitochondria, molecular biology, neuronal plasticity, neuroprotection, oral biology, oxidative stress, pathology, pathophysiology, peroxidase, phagocytes, pharmacokinetics, physiology, potassium channel, reactive oxygen species, receptors redox homeostasis, regulation, signal transduction, small GTPases, stem cell, stress, stroke, superoxide, tetrasomi, tissue engineering, transplantation,  
  Laboratory of Cerebrovascular Research  Pediatric Nephrology Research Group  Antibiotic Resistance Research Unit  Ocular Surface and Cornea Laboratory  Clinical Nephrology Research Group  Laboratory of Comparative Neurocytology and Neuroethology  Corneal and Refractive Surgical Unit  Glaucoma Clinical and Research Group  Molecular and Cellular Neuroendocrine Research Laboratory  Laboratory of Corneal Wound Healing  Cerebrovascular Signaling Research Group  Laboratory of Molecular Genetics  Neuromorphological and Neuroendocrine Research Laboratory  Biochemical Pharmacology Unit  Laboratory of Tumor Biology  Laboratory of Molecular Endocrinology   
     Research Areas     

Behavioural sciences

  

Biochemistry, cell biology, biophysics

  

Dental sciences

  

Experimental and clinical immunology and genetics

  

Experimental and clinical oncology

  

Internal medicine and pediatrics

  

Medicine of sensory organs

  

Miscellaneous

  

Molecular biology, microbiology

  

Morphological sciences (anatomy, pathology, forensic medicine)

  

Neurosciences

  

Pharmaceutical sciences, pharmacology

  

Physiology, pathophysiology

  

Reproductive sciences

  

Sport sciences

  

Surgery (operative sciences)

  
    :: © 2009 - Semmelweis University :: Production - DataWeb Systems ::